万婷婷,李颖馨,张宇亭,贺家华,卞洋洋,刘晓晔

• 1:北京农学院动物医学院

摘要(Abstract)：

【目的】改善多重耐药细菌的抗生素治疗策略。【方法】综述组织细胞力学因素调控细菌内化的力学生物学机制。【结果】细菌层面，基质刚度影响细菌黏附、生物膜形成及群体感应系统响应，且存在物种特异性与非线性特征；宿主-细菌互作层面，宿主细胞经焦点黏附点、机械敏感离子通道等调控细菌内化效率与胞内命运；应用层面，刚度调控抗菌策略为克服耐药性提供新方向，相关互作模型也为机制解析奠定基础。【结论】深化了“力学-生化”信号协同调控感染动力学的认知，为优化耐药菌治疗方案、开发抗感染策略提供理论支撑。

关键词(KeyWords)： 组织细胞力学;细胞外基质刚度;细菌-细胞感染

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(32202864);; 北京市自然科学基金资助项目(6224060)

作者(Author): 万婷婷,李颖馨,张宇亭,贺家华,卞洋洋,刘晓晔

DOI: 10.13473/j.cnki.issn.1002-3186.2026.0321

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